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SIRP alpha

Brief Information

Name:Signal-regulatory protein alpha
Target Synonym:SHPS-1,Macrophage fusion receptor,Brain Ig-like molecule with tyrosine-based activation motifs,MFR,Signal-regulatory protein alpha-1,Signal-regulatory protein alpha-2,CD172a,MyD-1 antigen,Sirp-alpha-3,MYD1,SIRPA,Signal Regulatory Protein Alpha,CD172 Antigen-Like Family Member A,Inhibitory Receptor SHPS-1,PTPNS1,SHPS1,SIRP,P84,Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs,Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1,Tyrosine-Protein Phosphatase Non-Recept
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:15
Lastest Research Phase:Approved

Product ListCompare or Buy

Cat . Non Espèces Description du produit Structure Pureté Caractéristique
SIA-C82F3 Cynomolgus Biotinylated Cynomolgus SIRP alpha / CD172a Protein, Fc,Avitag™ (MALS verified)
SIA-C82F3-structure
SIA-C82F3-sds
CHEK-ATP051 Human HEK293/Human SIRP alpha Stable Cell Line
SIA-M82F7 Mouse Biotinylated Mouse SIRP alpha / CD172a Protein, Fc,Avitag™ (MALS verified)
SIA-M82F7-structure
SIA-M82F7-sds
SIA-R5255 Rat Rat SIRP alpha / CD172a Protein, Fc Tag (MALS verified)
SIA-R5255-structure
SIA-R5255-sds
SIA-H5258 Human Human SIRP alpha / CD172a (31-149) Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)
SIA-H5258-structure
SIA-H5258-sds
SIA-H5256 Human Human SIRP alpha / CD172a Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)
SIA-H5256-structure
SIA-H5256-sds
SIA-MP2H6 Mouse PE-Labeled Mouse SIRP alpha Protein, His Tag (Site-specific conjugation)
SIA-MP2H6-structure
SIA-C82E2 Cynomolgus Biotinylated Cynomolgus SIRP alpha / CD172a Protein, His,Avitag™ (MALS verified)
SIA-C82E2-structure
SIA-C82E2-sds
SIA-M82E2 Mouse Biotinylated Mouse SIRP alpha / CD172a Protein, His,Avitag™ (MALS verified)
SIA-M82E2-structure
SIA-M82E2-sds
SIA-H82A3 Human Biotinylated Human SIRP alpha / CD172a Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
SIA-H82A3-structure
SIA-H82A3-sds
SIA-HP252 Human PE-Labeled Human SIRP alpha / CD172a Protein, Fc Tag (recommended for neutralizing assay) (Site-specific conjugation)
SIA-HP252-structure
SIA-H82E0 Human Biotinylated Human SIRP alpha / CD172a Protein, His,Avitag™ (MALS verified)
SIA-H82E0-structure
SIA-H82E0-sds
SIA-M52H4 Mouse Mouse SIRP alpha / CD172a Protein, His Tag (MALS verified)
SIA-M52H4-structure
SIA-M52H4-sds
SIA-M5258 Mouse Mouse SIRP alpha / CD172a Protein, Fc Tag (MALS verified)
SIA-M5258-structure
SIA-M5258-sds
SIA-C5254 Cynomolgus Cynomolgus SIRP alpha / CD172a Protein, Fc Tag (MALS verified)
SIA-C5254-structure
SIA-C5254-sds
SIA-C52H7 Cynomolgus Cynomolgus SIRP alpha / CD172a Protein, His Tag (MALS verified)
SIA-C52H7-structure
SIA-C52H7-sds
SIA-M5252 Mouse Mouse SIRP alpha / CD172a Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
SIA-M5252-structure
SIA-M5252-sds
CDA-H82F2 Human Biotinylated Human SIRP alpha / CD172a Protein, Fc,Avitag™ (MALS verified)
CDA-H82F2-structure
CDA-H82F2-sds
SIA-H5225 Human Human SIRP alpha / CD172a Protein, His Tag (MALS verified)
SIA-H5225-structure
SIA-H5225-sds
SIA-H52A8 Human Human SIRP alpha / CD172a Protein, Mouse IgG1 Fc Tag (MALS verified)
SIA-H52A8-structure
SIA-H52A8-sds
SIA-H5251 Human Human SIRP alpha / CD172a Protein, Fc Tag (MALS verified)
SIA-H5251-structure
SIA-H5251-sds
ACRO Quality

Part of Bioactivity data

CHEK-ATP051-Cell-based assay
 SIRP alpha FACS

Fig. FACS analysis of SIRPα/β on HEK293/Human SIRP alpha Stable Cell Line.
FACS assay shows that Anti-SIRPα/β antibody can bind to HEK293/Human SIRP alpha Stable Cell Line. HEK293/Human SIRP alpha Stable Cell Line was red line, Negative control HEK293 cells was grey line (QC tested).

SIA-MP2H6-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of overexpressing mouse CD47 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Mouse SIRP alpha, His Tag (Cat. No. SIA-MP2H6) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

SIA-H5225-BLI
 SIRP alpha BLI

Loaded Human CD47, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD7-H52A5) on Protein A Biosensor, can bind Human SIRP alpha, His Tag (Cat. No. SIA-H5225) with an affinity constant of 1.1 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

SIA-H5225-BLI
 SIRP alpha BLI

Immobilized Human CD47, Fc Tag (Cat. No. CD7-H5256) on AHC Biosensor, can bind Human SIRP alpha, His Tag (Cat. No. SIA-H5225) with an affinity constant of 0.72 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Customer Reviews

Synonym Name

SIRP alpha,SHPS1,SIRPA,CD172A,BIT,SHPS-1,MFR,MYD-1,MYD1,PTPNS1,SIRPalpha,p84,SIRP-alpha,CD172

Background

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Relugolix/Estradiol/Norethindrone Acetate E2/NETA Approved Myovant Sciences MYFEMBREE, RYEQO United States Menorrhagia; Leiomyoma Myovant Sciences 2021-05-26 Pain; Endometriosis; Leiomyoma; Menorrhagia; Uterine Neoplasms Details
Elagolix/estradiol/norethindrone acetate Approved Abbvie Inc Oriahnn United States Menorrhagia Abbvie Inc 2020-05-29 Menorrhagia Details
Relugolix/Estradiol/Norethindrone Acetate E2/NETA Approved Myovant Sciences MYFEMBREE, RYEQO United States Menorrhagia; Leiomyoma Myovant Sciences 2021-05-26 Pain; Endometriosis; Leiomyoma; Menorrhagia; Uterine Neoplasms Details
Elagolix/estradiol/norethindrone acetate Approved Abbvie Inc Oriahnn United States Menorrhagia Abbvie Inc 2020-05-29 Menorrhagia Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
IBC-0966 IBC-0966 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Neoplasms Details
BI-765063 OSE-172; BI-765063 Phase 1 Clinical Ose Immunotherapeutics Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Anzurstobart BMS-986351; CC-95251 Phase 1 Clinical Celgene Corp Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
ADU-1805 ADU-1805 Phase 1 Clinical Aduro Biotech Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
LM-101 LM-101 Phase 1 Clinical LaNova Medicines Ltd Leukemia; Solid tumours; Hematologic Neoplasms; Neoplasms Details
Q-1801 Q-1801; Q 1801 Phase 1 Clinical Qiyu Biotechnology (Shanghai) Co Ltd Solid tumours Details
Recombinant humanized IgG4 anti-SIRPα antibody(Daiichi Sankyo) DS-1103a Phase 1 Clinical Daiichi Sankyo Co Ltd Solid tumours; Breast Neoplasms Details
ELA-026 ELA-026 Phase 1 Clinical Electra Therapeutics Inc Lymphohistiocytosis, Hemophagocytic Details
BYON-4228 BYON-4228 Phase 1 Clinical Byondis Bv Solid tumours; Lymphoma Details
BSI-082 BSI-082 Phase 1 Clinical Boaoxin Biotechnology(Nanjing) Co Ltd Hematologic Neoplasms; Solid tumours Details
BR-105 BR-105; BR105 Phase 1 Clinical BioRay Pharmaceutical Co Ltd Neoplasms Details
[89Zr]Zr- BI-765063(Boehringer Ingelheim) Phase 1 Clinical Boehringer Ingelheim Corp Squamous Cell Carcinoma of Head and Neck; Carcinoma, Non-Small-Cell Lung; Melanoma Details
TQB-2928 TQB-2928 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Hematologic Neoplasms; Solid tumours; Myelodysplastic Syndromes; Neoplasms; Leukemia, Myeloid, Acute Details
BI-765080 Phase 1 Clinical C.H. Boehringer Sohn Ag & Co. Kg Details
ES-004 ES-004; ES 004-N4; ES 004-B4 Phase 1 Clinical Elpiscience (Shanghai) Biopharma Ltd Solid tumours; Neoplasms Details
IBC-0966 IBC-0966 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Neoplasms Details
BI-765063 OSE-172; BI-765063 Phase 1 Clinical Ose Immunotherapeutics Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Anzurstobart BMS-986351; CC-95251 Phase 1 Clinical Celgene Corp Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
ADU-1805 ADU-1805 Phase 1 Clinical Aduro Biotech Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
LM-101 LM-101 Phase 1 Clinical LaNova Medicines Ltd Leukemia; Solid tumours; Hematologic Neoplasms; Neoplasms Details
Q-1801 Q-1801; Q 1801 Phase 1 Clinical Qiyu Biotechnology (Shanghai) Co Ltd Solid tumours Details
Recombinant humanized IgG4 anti-SIRPα antibody(Daiichi Sankyo) DS-1103a Phase 1 Clinical Daiichi Sankyo Co Ltd Solid tumours; Breast Neoplasms Details
ELA-026 ELA-026 Phase 1 Clinical Electra Therapeutics Inc Lymphohistiocytosis, Hemophagocytic Details
BYON-4228 BYON-4228 Phase 1 Clinical Byondis Bv Solid tumours; Lymphoma Details
BSI-082 BSI-082 Phase 1 Clinical Boaoxin Biotechnology(Nanjing) Co Ltd Hematologic Neoplasms; Solid tumours Details
BR-105 BR-105; BR105 Phase 1 Clinical BioRay Pharmaceutical Co Ltd Neoplasms Details
[89Zr]Zr- BI-765063(Boehringer Ingelheim) Phase 1 Clinical Boehringer Ingelheim Corp Squamous Cell Carcinoma of Head and Neck; Carcinoma, Non-Small-Cell Lung; Melanoma Details
TQB-2928 TQB-2928 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Hematologic Neoplasms; Solid tumours; Myelodysplastic Syndromes; Neoplasms; Leukemia, Myeloid, Acute Details
BI-765080 Phase 1 Clinical C.H. Boehringer Sohn Ag & Co. Kg Details
ES-004 ES-004; ES 004-N4; ES 004-B4 Phase 1 Clinical Elpiscience (Shanghai) Biopharma Ltd Solid tumours; Neoplasms Details

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